Table 2

Pharmacokinetic parameters of DTX after i.v. administration of DTX-loaded Polysorbate 80 micelles and DTX-loaded Polysorbate 80/Phospholipid mixed micelles to mice.

Parameters

Unit

DTX-loaded Polysorbate80 micelles

DTX-loadedPolysorbate 80/Phospholipid mixed micelles

P


t1/2α

h

0.682 ± 0.2088

0.634 ± 0.166

0.734

t1/2β

h

15.790 ± 20.5700

5.695 ± 1.703

0.445

K12

h-1

13.976 ± 7.9457

9.627 ± 6.878

0.440

K21

h-1

2.198 ± 0.2320

2.739 ± 1.032

0.346

K13

h-1

4.410 ± 1.4573

1.012 ± 0.687

0.022*

K31

h-1

0.149 ± 0.108

0.155 ± 0.042

0.927

K10

h-1

16.040 ± 12.268

14.245 ± 16.245

0.866

AUC0-8 h

μg∙L-1 ∙h

10466.290 ± 3122.821

11406.914 ± 5042.349

0.762

Cl

L∙h

0.009 ± 0.007

0.008 ± 0.003

0.776


n = 4. Mean ± SD.

* P < 0.05, denotes significant difference between two groups.

Song et al. Nanoscale Research Letters 2011 6:354   doi:10.1186/1556-276X-6-354

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