Table 2 |
||||
|
Pharmacokinetic parameters of DTX after i.v. administration of DTX-loaded Polysorbate 80 micelles and DTX-loaded Polysorbate 80/Phospholipid mixed micelles to mice. |
||||
|
Parameters |
Unit |
DTX-loaded Polysorbate80 micelles |
DTX-loadedPolysorbate 80/Phospholipid mixed micelles |
P |
|
|
||||
|
t1/2α |
h |
0.682 ± 0.2088 |
0.634 ± 0.166 |
0.734 |
|
t1/2β |
h |
15.790 ± 20.5700 |
5.695 ± 1.703 |
0.445 |
|
K12 |
h-1 |
13.976 ± 7.9457 |
9.627 ± 6.878 |
0.440 |
|
K21 |
h-1 |
2.198 ± 0.2320 |
2.739 ± 1.032 |
0.346 |
|
K13 |
h-1 |
4.410 ± 1.4573 |
1.012 ± 0.687 |
0.022* |
|
K31 |
h-1 |
0.149 ± 0.108 |
0.155 ± 0.042 |
0.927 |
|
K10 |
h-1 |
16.040 ± 12.268 |
14.245 ± 16.245 |
0.866 |
|
AUC0-8 h |
μg∙L-1 ∙h |
10466.290 ± 3122.821 |
11406.914 ± 5042.349 |
0.762 |
|
Cl |
L∙h |
0.009 ± 0.007 |
0.008 ± 0.003 |
0.776 |
|
|
||||
|
n = 4. Mean ± SD. * P < 0.05, denotes significant difference between two groups. |
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|
Song et al. Nanoscale Research Letters 2011 6:354 doi:10.1186/1556-276X-6-354 |
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