Table 1

Pharmacokinetic parameters of DTX after i.v. administration of DTX-loaded Polysorbate 80 micelles and DTX-loaded Polysorbate 80/Phospholipid mixed micelles to rats.

Parameters

Unit

DTX-loaded Polysorbate 80 micelles

DTX-loaded Polysorbate 80/Phospholipid mixed micelles

P


t1/2α

h

0.916 ± 0.608

0.919 ± 0.601

0.995

t1/2β

h

4.901 ± 2.453

6.726 ± 1.684

0.626

K12

h-1

4.780 ± 2.525

2.886 ± 1.551

0.179

K21

h-1

2.544 ± 1.187

2.376 ± 1.421

0.828

K13

h-1

0.773 ± 0.581

2.350 ± 1.577

0.095

K31

h-1

0.190 ± 0.122

0.376 ± 0.404

0.310

K10

h-1

2.800 ± 0.897

2.735 ± 0.891

0.908

AUC0-12 h

μg∙L-1∙h

2024.891 ± 287.679

2218.685 ± 407.753

0.379

Cl

L∙h

0.038 ± 0.006

0.038 ± 0.007

0.468


n = 6.

Mean ± SD.

Song et al. Nanoscale Research Letters 2011 6:354   doi:10.1186/1556-276X-6-354

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