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T cells enhance gold nanoparticle delivery to tumors in vivo

Laura C Kennedy1, Adham S Bear2, Joseph K Young3, Nastassja A Lewinski1, Jean Kim1, Aaron E Foster2* and Rebekah A Drezek13*

Author Affiliations

1 Department of Bioengineering, Rice University, Houston, TX 77005, USA

2 Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, Houston, TX 77030, USA

3 Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA

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Nanoscale Research Letters 2011, 6:283  doi:10.1186/1556-276X-6-283

Published: 4 April 2011

Additional files

Additional file 1:

Figure S1 Gold colloid size distribution. Particle sizes were determined using TEM. A total of 585 particles were examined over multiple images to generate the histogram. Figure S2 AuNP-loading does not affect T cell phenotype. T cells were loaded in the presence of 0.5 nM AuNP for 24 h and subsequently stained with a panel of antibodies and analyzed by flow cytometry.

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