Table 2

The effect of molar ratio of Solutol HS15 to mPEG-PLA on properties of micelles.

Molar ratio of Solutol HS15 to mPEG-PLA

0:10

1:9

5:5

7:3


Drug-free micelles size (nm)

88.1 ± 4.1

83.3 ± 3.5

80.2 ± 3.6

78.3 ± 5.1

PDI

0.16 ± 0.03

0.17 ± 0.04

0.19 ± 0.07

0.16 ± 0.06

Drug-loaded micelles size (nm)

119.9 ± 5.5

117.1 ± 6.1

101.0 ± 3.8

94.4 ± 6.4

PDI

0.17 ± 0.11

0.19 ± 0.04

0.12 ± 0.09

0.18 ± 0.08

LC (%)

21.1 ± 3.2

26.5 ± 1.5*

32.4 ± 1.3**

36.0 ± 2.4***


* p > 0.05 versus plain micelles

** p < 0.01 versus plain micelles

*** p > 0.05 versus mixed micelles with 5:5 molar ratio of Solutol HS15 to mPEG-PLA

Li et al. Nanoscale Research Letters 2011 6:275   doi:10.1186/1556-276X-6-275

Open Data