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Hydroxyapatite Mineralization on the Calcium Chloride Blended Polyurethane Nanofiber via Biomimetic Method

R Nirmala1, Ki Taek Nam2, R Navamathavan3, Soo-Jin Park2 and Hak Yong Kim2*

Author affiliations

1 Bio-Nano System Engineering, College of Engineering, Chonbuk National University, Jeonju 561 756, South Korea

2 Center for Healthcare Technology and Development, Chonbuk National University, Jeonju 561 756, South Korea

3 School of Advanced Materials Engineering, Chonbuk National University, Jeonju 561 756, South Korea

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Citation and License

Nanoscale Res Lett 2011, 6:2  doi:10.1007/s11671-010-9737-4

Published: 19 August 2010


Polyurethane nanofibers containing calcium chloride (CaCl2) were prepared via an electrospinning technique for the biomedical applications. Polyurethane nanofibers with different concentration of CaCl2 were electrospun, and their bioactivity evaluation was conducted by incubating in biomimetic simulated body fluid (SBF) solution. The morphology, structure and thermal properties of the polyurethane/CaCl2 composite nanofibers were characterized by means of scanning electron microscopy (SEM), field-emission scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy and thermogravimetry. SEM images revealed that the CaCl2 salt incorporated homogeneously to form well-oriented nanofibers with smooth surface and uniform diameters along their lengths. The SBF incubation test confirmed the formation of apatite-like materials, exhibiting enhanced bioactive behavior of the polyurethane/CaCl2 composite nanofibers. This study demonstrated that the electrospun polyurethane containing CaCl2 composite nanofibers enhanced the in vitro bioactivity and supports the growth of apatite-like materials.

Polyurethane; Electrospinning; Nanofibers; Simulated body fluid; Bioactivity