Open Access Nano Express

Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics

Suguna Lakshmi Madurai1, Stella Winnarasi Joseph1, Asit Baran Mandal1, John Tsibouklis2 and Boreddy SR Reddy1*

Author Affiliations

1 Industrial Chemistry Laboratory, Central Leather Research Institute, Council of Scientific and Industrial Research, Chennai 600 020, India

2 Biomaterials & Drug Delivery Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, Hampshire PO1 2DT, UK

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Nanoscale Res Lett 2011, 6:15  doi:10.1007/s11671-010-9749-0

Published: 27 August 2010

Abstract

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

Keywords:
Captopril montmorillonite; Intercalation; Intestine-specific controlled release; Release kinetics