Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics
1 Industrial Chemistry Laboratory, Central Leather Research Institute, Council of Scientific and Industrial Research, Chennai 600 020, India
2 Biomaterials & Drug Delivery Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, Hampshire PO1 2DT, UK
Nanoscale Res Lett 2011, 6:15 doi:10.1007/s11671-010-9749-0Published: 27 August 2010
The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.