Open Access Nano Express

Preparation and Sustained-Release Property of Triblock Copolymer/Calcium Phosphate Nanocomposite as Nanocarrier for Hydrophobic Drug

Shao-Wen Cao12, Ying-Jie Zhu12*, Jin Wu12, Ke-Wei Wang12 and Qi-Li Tang12

Author Affiliations

1 State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 200050, Shanghai, People’s Republic of China

2 Graduate School of Chinese Academy of Sciences, Shanghai, People’s Republic of China

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Nanoscale Research Letters 2010, 5:781-785  doi:10.1007/s11671-010-9558-5

Published: 14 February 2010

Abstract

The P123/ACP nanocomposite with sizes less than 100 nm consisting of triblock copolymer P123 and amorphous calcium phosphate (ACP) has been prepared by using an aqueous solution containing CaCl2, (NH4)3PO4, and P123 at room temperature. The P123/ACP nanocomposite is used as the nanocarrier for hydrophobic drug ibuprofen, based on the combined advantages of both amphiphilic block copolymer and calcium phosphate delivery system. The P123/ACP nanocomposite has a much higher ibuprofen loading capacity (148 mg/g) than the single-phase calcium phosphate nanostructures. The drug release percentage of the P123/ACP nanocomposite in simulated body fluid reaches about 100% in a period of 156 h, which is much slower than that of single-phase calcium phosphate nanostructures. It is expected that the P123/ACP nanocomposite is promising for the application in the controlled delivery of hydrophobic drugs.

Keywords:
Nanocomposite; P123; Calcium phosphate; Hydrophobic drug; Sustained release