Open Access Nano Express

CdTe Quantum Dot/Dye Hybrid System as Photosensitizer for Photodynamic Therapy

Aliaksandra Rakovich1, Diana Savateeva2, Tatsiana Rakovich3, John F Donegan1, Yury P Rakovich1*, Vincent Kelly3, Vladimir Lesnyak4 and Alexander Eychmüller4

Author Affiliations

1 School of Physics and CRANN Research Centre, Trinity College, Dublin 2, Ireland

2 Brest State Technical University, 224017, Brest, Belarus

3 School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland

4 Physikalische Chemie/Elektrochemie, TU Dresden, Bergstr. 66b, 01062, Dresden, Germany

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Nanoscale Research Letters 2010, 5:753-760  doi:10.1007/s11671-010-9553-x

Published: 10 February 2010

Abstract

We have studied the photodynamic properties of novel CdTe quantum dots—methylene blue hybrid photosensitizer. Absorption spectroscopy, photoluminescence spectroscopy, and fluorescence lifetime imaging of this system reveal efficient charge transfer between nanocrystals and the methylene blue dye. Near-infrared photoluminescence measurements provide evidence for an increased efficiency of singlet oxygen production by the methylene blue dye. In vitro studies on the growth of HepG2 and HeLa cancerous cells were also performed, they point toward an improvement in the cell kill efficiency for the methylene blue-semiconductor nanocrystals hybrid system.

Keywords:
Quantum dots; Nanocrystals; Photosensitiser; Electron transfer; Singlet oxygen