CdTe Quantum Dot/Dye Hybrid System as Photosensitizer for Photodynamic Therapy
1 School of Physics and CRANN Research Centre, Trinity College, Dublin 2, Ireland
2 Brest State Technical University, 224017, Brest, Belarus
3 School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
4 Physikalische Chemie/Elektrochemie, TU Dresden, Bergstr. 66b, 01062, Dresden, Germany
Nanoscale Research Letters 2010, 5:753-760 doi:10.1007/s11671-010-9553-xPublished: 10 February 2010
We have studied the photodynamic properties of novel CdTe quantum dots—methylene blue hybrid photosensitizer. Absorption spectroscopy, photoluminescence spectroscopy, and fluorescence lifetime imaging of this system reveal efficient charge transfer between nanocrystals and the methylene blue dye. Near-infrared photoluminescence measurements provide evidence for an increased efficiency of singlet oxygen production by the methylene blue dye. In vitro studies on the growth of HepG2 and HeLa cancerous cells were also performed, they point toward an improvement in the cell kill efficiency for the methylene blue-semiconductor nanocrystals hybrid system.