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Open Access Nano Express

Nanodiamonds as Carriers for Address Delivery of Biologically Active Substances

KV Purtov1*, AI Petunin2, AE Burov3, AP Puzyr1 and VS Bondar1

Author Affiliations

1 Institute of Biophysics SB RAS, Krasnoyarsk, Russia

2 Medical Research Company «Dias», Krasnoyarsk, Russia

3 Institute of Computational Modeling SB RAS, Krasnoyarsk, Russia

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Nanoscale Research Letters 2010, 5:631-636  doi:10.1007/s11671-010-9526-0

Published: 19 January 2010

Abstract

Surface of detonation nanodiamonds was functionalized for the covalent attachment of immunoglobulin, and simultaneously bovine serum albumin and Rabbit Anti-Mouse Antibody. The nanodiamond-IgGI125 and RAM-nanodiamond-BSAI125 complexes are stable in blood serum and the immobilized proteins retain their biological activity. It was shown that the RAM-nanodiamond-BSAI125 complex is able to bind to the target antigen immobilized on the Sepharose 6B matrix through antibody–antigen interaction. The idea can be extended to use nanodiamonds as carriers for delivery of bioactive substances (i.e., drugs) to various targets in vivo.

Keywords:
Nanodiamonds; Ligand; Protein immobilization; Nanocarrier; Targeted delivery