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Open Access Special Issue Article

Finite-Element Modelling of Biotransistors

MW Shinwari1*, MJ Deen1 and PR Selvaganapathy2

Author Affiliations

1 Department of Electrical Engineering, McMaster University, 1280 Main St. West, Hamilton, ON, L8S 4K1, Canada

2 Department of Mechanical Engineering, McMaster University, 1280 Main St. West, Hamilton, ON, L8S 4L7, Canada

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Nanoscale Research Letters 2010, 5:494-500  doi:10.1007/s11671-009-9522-4

Published: 19 January 2010

Abstract

Current research efforts in biosensor design attempt to integrate biochemical assays with semiconductor substrates and microfluidic assemblies to realize fully integrated lab-on-chip devices. The DNA biotransistor (BioFET) is an example of such a device. The process of chemical modification of the FET and attachment of linker and probe molecules is a statistical process that can result in variations in the sensed signal between different BioFET cells in an array. In order to quantify these and other variations and assess their importance in the design, complete physical simulation of the device is necessary. Here, we perform a mean-field finite-element modelling of a short channel, two-dimensional BioFET device. We compare the results of this model with one-dimensional calculation results to show important differences, illustrating the importance of the molecular structure, placement and conformation of DNA in determining the output signal.

Keywords:
Biosensor; Microarray; DNA; Model; Sensitivity