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Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents

Sang Young Jeong1, Hyo Jeong Kim2, Byung-Kook Kwak3, Ha-Young Lee2, Hasoo Seong2, Byung Cheol Shin2, Soon Hong Yuk2, Sung-Joo Hwang1* and Sun Hang Cho2*

Author Affiliations

1 College of Pharmacy, Chungnam National University, 220 Gung-dong, Yuseong-gu, Daejeon, 305-764, South Korea

2 Center for Drug Discovery Technology, KRICT, 100 Jang-dong, Yuseong-gu, Daejeon, 305-600, South Korea

3 College of Medicine, Chung-Ang University, 224-1 Heuksuk-dong, Dongjak-gu, Seoul, 156-756, South Korea

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Nanoscale Research Letters 2010, 5:1970-1976  doi:10.1007/s11671-010-9734-7

Published: 2 September 2010


Biocompatible poly-[N-(2-hydroxyethyl)-D,L-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C16) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C16-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesized materials were characterized by proton nuclear magnetic resonance (1H NMR). Micelle size and shape were examined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Micelles with PHEA-mPEG-C16-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent. Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C16-ED-DOTA-Gd.

MRI contrast agent; PHEA derivatives; Micelles; Nanoparticles; Gd contrast agent