Figure 7.
The lethality and immunogenicity of surface-modified 17 nm GNPs. Average lifespans
of mice injected with modified 17 nm GNPs are shown in empty columns. Each experimental
group received GNP conjugated with BSA, lysozyme, pFMDV, or pH5N1. Unmodified GNPs
served as a positive control (17 nm GNP). Titers of antiserum withdrawn from GNP-injected
mice against corresponding antigens are shown in filled columns. pH5N1- and pFMDV-coated
GNPs induced the highest titer in mouse serum; BSA- and lysozyme-coated GNPs induced
a moderate titer; and unmodified GNPs did not induce an antibody response in mice
(*)
Chen et al. Nanoscale Research Letters 2009 4:858 doi:10.1007/s11671-009-9334-6 |
