Open Access Nano Express

Accelerated Hydrolysis of Aspirin Using Alternating Magnetic Fields

Uwe M Reinscheid

Author Affiliations

Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Göttingen, Germany

Nanoscale Research Letters 2009, 4:854-857  doi:10.1007/s11671-009-9332-8

Published: 7 May 2009

Abstract

The major problem of current drug-based therapy is selectivity. As in other areas of science, a combined approach might improve the situation decisively. The idea is to use the pro-drug principle together with an alternating magnetic field as physical stimulus, which can be applied in a spatially and temporarily controlled manner. As a proof of principle, the neutral hydrolysis of aspirin in physiological phosphate buffer of pH 7.5 at 40 °C was chosen. The sensor and actuator system is a commercially available gold nanoparticle (NP) suspension which is approved for animal usage, stable in high concentrations and reproducibly available. Applying the alternating magnetic field of a conventional NMR magnet system accelerated the hydrolysis of aspirin in solution.

Keywords:
Gold nanoparticle; Magnetic field; Relaxation; Hydrolysis; Pro-drug