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A Novel Approach to Molecular Recognition Surface of Magnetic Nanoparticles Based on Host–Guest Effect

Yuanpeng Wu13, Fang Zuo2, Zhaohui Zheng1, Xiaobin Ding1* and Yuxing Peng1*

Author Affiliations

1 Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, People’s Republic of China

2 Research Branch of Functional Materials, State Key Laboratory of Electronic Films & Integrated Devices, University of Electronic Science and Technology of China, Chengdu, 610054, People’s Republic of China

3 Graduate School of the Chinese Academy of Sciences, Beijing, 100049, People’s Republic of China

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Nanoscale Research Letters 2009, 4:738-747  doi:10.1007/s11671-009-9314-x

Published: 23 April 2009


A novel route has been developed to prepared β-cyclodextrin (β-CD) functionalized magnetic nanoparticles (MNPs). The MNPs were first modified with monotosyl-poly(ethylene glycol) (PEG) silane and then tosyl units were displaced by amino-β-CD through the nucleophilic substitution reaction. The monotosyl-PEG silane was synthesized by modifying a PEG diol to form the corresponding monotosyl-PEG, followed by a reaction with 3-isocyanatopropyltriethoxysilane (IPTS). The success of the synthesis of the monotosyl-PEG silane was confirmed with1H NMR and Fourier transform infrared (FTIR) spectroscopy. The analysis of FTIR spectroscopy and X-ray photoelectron spectroscopy (XPS) confirmed the immobilization of β-CD onto MNPs. Transmission electron microscopy (TEM) indicated that the β-CD functionalized MNPs were mostly present as individual nonclustered units in water. The number of β-CD molecules immobilized on each MNP was about 240 according to the thermogravimetric analysis (TGA) results. The as-prepared β-CD functionalized MNPs were used to detect dopamine with the assistance of a magnet.

β-Cyclodextrin; Magnetic nanoparticles; Molecular recognition; Dopamine