Open Access Nano Express

Nanostructured Biomaterials with Controlled Properties Synthesis and Characterization

Eugenia Teodor1*, SimonaCarmen Liţescu1, C Petcu2, Mihaela Mihalache1 and Raluca Somoghi2

Author Affiliations

1 National Institute for Biological Sciences-Centre of Bioanalysis, 296 Spl. Independentei, Bucharest 6, Romania

2 National Institute for Chemistry & Petrochemistry, 202 Spl. Independentei, Bucharest 6, Romania

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Nanoscale Research Letters 2009, 4:544-549  doi:10.1007/s11671-009-9278-x

Published: 6 March 2009

Abstract

Magnetic nanoparticles were obtained using an adjusted Massart method and were covered in a layer-by-layer technique with hydrogel-type biocompatible shells, from chitosan and hyaluronic acid. The synthesized nanocomposites were characterized using dynamic light scattering, transmission electron microscopy, and Fourier transformed infrared spectroscopy. Biocompatibility of magnetic nanostructures was determined by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) cell proliferation assay, swelling tests, and degradation tests. In addition, interaction of hydrogel-magnetic nanoparticles with microorganisms was studied. The possibility of precise nanoparticles size control, as long as the availability of bio-compatible covering, makes them suitable for biomedical applications.

Keywords:
Magnetic nanoparticles; Hydrogels; Layer-by-layer technique; Biocompatibility