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pH-Sensitive Micelles Based on Double-Hydrophilic Poly(methylacrylic acid)-Poly(ethylene glycol)-Poly(methylacrylic acid) Triblock Copolymer

Youhua Tao12, Ren Liu13, Xiaoya Liu13*, Mingqing Chen13, Cheng Yang13 and Zhongbin Ni13

Author Affiliations

1 School of Chemical and Material Engineering, Jiangnan University, Wuxi, 214122, People’s Republic of China

2 State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, People’s Republic of China

3 State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, People’s Republic of China

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Nanoscale Research Letters 2009, 4:341-343  doi:10.1007/s11671-009-9249-2

Published: 21 January 2009


pH-sensitive micelles with hydrophilic core and hydrophilic corona were fabricated by self-assembling of triblock copolymer of poly(methylacrylic acid)-poly(ethylene glycol)-poly(methylacrylic acid) at lower solution pH. Transmission electron microscopy and laser light scattering studies showed micelles were in nano-scale with narrow size distribution. Solution pH value and the micelles concentration strongly influenced the hydrodynamic radius of the spherical micelles (48–310 nm). A possible mechanism for the formation of micelles was proposed. The obtained polymeric micelle should be useful for biomedical materials such as carrier of hydrophilic drug.

Self-assembly; Micelles; Double-hydrophilic; Triblock copolymers