Open Access Nano Express

Synergistic Effect of Functionalized Nickel Nanoparticles and Quercetin on Inhibition of the SMMC-7721 Cells Proliferation

Dadong Guo1, Chunhui Wu1, Jingyuan Li1, Airong Guo1, Qingning Li1, Hui Jiang1, Baoan Chen2 and Xuemei Wang1*

Author Affiliations

1 State Key Lab of Bioelectronics (Chien-Shiung Wu Lab), Southeast University, 210096, Nanjing, China

2 Zhongda Hospital, School of Clinical Medical, Southeast University, 210096, Nanjing, China

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Nanoscale Research Letters 2009, 4:1395-1402  doi:10.1007/s11671-009-9411-x

Published: 23 August 2009

Abstract

The effect of functionalized nickel (Ni) nanoparticles capped with positively charged tetraheptylammonium on cellular uptake of drug quercetin into hepatocellular carcinoma cells (SMMC-7721) has been explored in this study via microscopy and electrochemical characterization as well as MTT assay. Meanwhile, the influence of Ni nanoparticles and/or quercetin on cell proliferation has been further evaluated by the real-time cell electronic sensing (RT-CES) study. Our observations indicate that Ni nanoparticles could efficiently improve the permeability of cancer cell membrane, and remarkably enhance the accumulation of quercetin in SMMC-7721 cells, suggesting that Ni nanoparticles and quercetin would facilitate the synergistic effect on inhibiting proliferation of cancer cells.

Keywords:
Nickel nanoparticles; Real-time cell electronic sensing (RT-CES) study; MTT assay; Electrochemical analysis; Hepatocellular carcinoma cell line