Table 4

Effects of nano-Tio2on the cytokine protein level of mice by ELISA analysis after intraperitoneal injection with nano-anatase TiO2suspensions for consecutive 14 days
Nano-anatase (mg/kg BW) NF-κB (ng/mL) MIF (pg/mL) IL-1β (pg/mL) IL-6 (pg/mL) CRP (ng/mL) TNF-α (pg/mL) IL-4 (pg/mL) IL-10 (pg/mL)
0 1,819 ± 91 1,157 ± 58 482 ± 24 179 ± 9 103 ± 5 156 ± 8 1,079 ± 54 615 ± 31
5 2,434 ± 122* 1,341 ± 67* 599 ± 30* 202 ± 10* 153 ± 8** 190 ± 10** 1,216 ± 61* 773 ± 39*
10 3,852 ± 193** 1,529 ± 76** 669 ± 34** 303 ± 15** 204 ± 0** 226 ± 11** 1,304 ± 65* 1,617 ± 81**
50 4,511 ± 226** 1,789 ± 89** 736 ± 37** 422 ± 21** 266 ± 13** 294 ± 15** 1,399 ± 70* 1,869 ± 94**
100 5,738 ± 287** 2,326 ± 116** 848 ± 42** 541 ± 27** 327 ± 16** 346 ± 17** 1,490 ± 75** 2,081 ± 104**
150 6,819 ± 341** 3,098 ± 155** 979 ± 49** 699 ± 35** 428 ± 21** 596 ± 30** 1,717 ± 86** 2,403 ± 120**
150-bulk 3,838 ± 192** 1,401 ± 70* 612 ± 31* 391 ± 20** 175 ± 9** 202 ± 10** 1,330 ± 67* 1,027 ± 51*

Ranks marked with a an asterisk or double asterisks means it is significantly different from the control (no nano-anatase or bulk TiO2) at the 5 or 1% confidence level, respectively. Values represent mean ± SE,n = 5

Ma et al.

Ma et al. Nanoscale Research Letters 2009 4:1275-1285   doi:10.1007/s11671-009-9393-8

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