Table 2

The changes of biochemical parameters in the blood serum of mouse liver after intraperitoneal injection with nano-anatase TiO2suspensions for consecutive 14 days
Indexes Nano-anatase (mg/kg BW) Bulk (mg/kg BW)
0 5 10 50 100 150 150
ALT (U/L) 68.95 ± 3.45 72.66 ± 3.63 86.89 ± 0.34* 99.18 ± 4.96* 106.79 ± 5.34** 129.33 ± 6.47** 89.86 ± 4.49*
ALP (U/L) 208.59 ± 10.43 212.39 ± 10.62 234.72 ± 11.74 256.88 ± 12.84* 282.36 ± 14.12** 329.87 ± 16.49** 228.96 ± 11.45**
AST (U/L) 199.73 ± 9.99 210.47 ± 10.52 236.68 ± 11.83 268.92 ± 13.45** 297.55 ± 14.88** 345.88 ± 17.29** 246.78 ± 12.34**
LDH (U/L) 1,520 ± 76 1,623 ± 84 1,897 ± 95 2,318 ± 116* 2,689 ± 134** 2,949 ± 147** 2,309 ± 115*
PChE (U/L) 1,169 ± 58 1,297 ± 65 1,409 ± 70 1,696 ± 85* 1,988 ± 99** 2,597 ± 130** 1,647 ± 82*
LAP (U/L) 43.76 ± 2.19 47.25 ± 2.36 50.28 ± 2.51 56.81 ± 2.84* 60.19 ± 3.01* 63.66 ± 3.18* 52.72 ± 2.64*
TP (g/L) 60.15 ± 3.01 61.06 ± 3.05 62.59 ± 3.13 65.34 ± 3.27* 69.23 ± 3.46* 72.85 ± 3.64* 62.06 ± 3.10
ALB (g/L) 34.22 ± 1.71 34.30 ± 1.72 34.79 ± 1.74 35.92 ± 1.80 37.23 ± 1.86* 38.92 ± 1.95* 34.34 ± 1.72
GLB (g/L) 24.55 ± 1.23 24.98 ± 1.25 26.15 ± 1.31 27.44 ± 1.37* 30.15 ± 1.51* 33.57 ± 1.68** 25.05 ± 1.25
ALB/GLB 1.39 1.37 1.33 1.31* 1.24* 1.16** 1.37
TBIL (μmol/L) 1.35 ± 0.07 1.33 ± 0.07 1.29 ± 0.06 1.22 ± 0.06* 1.19 ± 0.06* 1.15 ± 0.06* 1.30 ± 0.06
TG (mmol/L) 1.66 ± 0.08 1.68 ± 0.08 1.72 ± 0.09 1.83 ± 0.09* 2.07 ± 0.10* 2.25 ± 0.11** 1.79 ± 0.09
TCHO (mmol/L) 3.19 ± 0.16 3.14 ± 0.16 3.21 ± 0.16 3.29 ± 0.16 3.51 ± 0.18* 3.66 ± 0.18* 3.57 ± 0.18*
HDLC (mmol/L) 2.86 ± 0.14 2.83 ± 0.14 2.91 ± 0.14 3.01 ± 0.15 3.34 ± 0.17* 3.52 ± 0.18* 3.36 ± 0.17*
LDLC (mmol/L) 0.26 ± 0.01 0.25 ± 0.01 0.22 ± 0.01 0.17 ± 0.01* 0.15 ± 0.01* 0.12 ± 0.01* 0.19 ± 0.01

Ranks marked with an asterisk or double asterisks means it is significantly different from the control (no nano-anatase or bulk TiO2) at the 5 or 1% confidence level, respectively. Values represent mean ± SE,n = 5

Ma et al.

Ma et al. Nanoscale Research Letters 2009 4:1275-1285   doi:10.1007/s11671-009-9393-8

Open Data