Figure 4.

Ultrastructure of hepatocyte (×8,000 or ×10,000) in female mice after intraperitoneal injection with various doses of nano-anatase TiO2suspensions for consecutive 14 days.aControl (×8,000): chromatin is well distributed, mitochondria turn round or oval and complete;b5 mg/kg BW nano-anatase TiO2(×8,000): hepatocyte indicates normal;c100 mg/kg BW nano-anatase TiO2(×10,000);arrowsindicate tumescent mitochondria and vacuolization;d150 mg/kg BW nano-anatase TiO2(×10,000): apoptotic cell or apoptotic body is observed

Ma et al. Nanoscale Research Letters 2009 4:1275-1285   doi:10.1007/s11671-009-9393-8