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Open Access Nano Express

The Effect of Iron Oxide Magnetic Nanoparticles on Smooth Muscle Cells

Song Zhang1, Xiangjian Chen2, Chunrong Gu2, Yu Zhang1, Jindan Xu2, Zhiping Bian2, Di Yang2* and Ning Gu1*

Author Affiliations

1 State Key Laboratory of Molecule and Biomolecule Electronics, Jiangsu Provincial Laboratory for Biomaterials and Devices, Southeast University, 210096, Nanjing, People’s Republic of China

2 Institute of Cardiovascular Disease, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, People’s Republic of China

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Nanoscale Research Letters 2008, 4:70-77  doi:10.1007/s11671-008-9204-7

Published: 2 December 2008

Abstract

Recently, magnetic nanoparticles of iron oxide (Fe3O4, γ-Fe2O3) have shown an increasing number of applications in the field of biomedicine, but some questions have been raised about the potential impact of these nanoparticles on the environment and human health. In this work, the three types of magnetic nanoparticles (DMSA-Fe2O3, APTS-Fe2O3, and GLU-Fe2O3) with the same crystal structure, magnetic properties, and size distribution was designed, prepared, and characterized by transmission electronic microscopy, powder X-ray diffraction, zeta potential analyzer, vibrating sample magnetometer, and Fourier transform Infrared spectroscopy. Then, we have investigated the effect of the three types of magnetic nanoparticles (DMSA-Fe2O3, APTS-Fe2O3, and GLU-Fe2O3) on smooth muscle cells (SMCs). Cellular uptake of nanoparticles by SMC displays the dose, the incubation time and surface property dependent patterns. Through the thin section TEM images, we observe that DMSA-Fe2O3is incorporated into the lysosome of SMCs. The magnetic nanoparticles have no inflammation impact, but decrease the viability of SMCs. The other questions about metabolism and other impacts will be the next subject of further studies.

Keywords:
Magnetic nanoparticles; Iron oxide; Smooth muscle cells; Cellular uptake; Viability