Table 1

Organic macromolecules and their advantages of functionalized iron oxide NPs
Polymers Advantages References
Natural Polymers Dextran Enables optimum polar interactions with iron oxide surfaces, improves the blood circulation time, stability, and biocompatibility [64-67]
Starch Improves the biocompatibility, good for MRI, and drug target delivery [68,69]
Gelatin Used as a gelling agent, hydrophilic emulsifier, biocompatible [70-72]
Chitosan Non-toxic, alkaline, hydrophilic, widely used as non-viral gene delivery system, biocompatible, and hydrophilic [73-75]
Synthetic Polymers Poly(ethyleneglycol) (PEG) Enhance the hydrophilicity and water-solublility, improves the biocompatibility, blood circulation times [76-78]
Poly(vinyl alcohol) (PVA) Prevents agglomeration, giving rise to monodispersibility [79-81]
Poly(lactide acid) (PLA) Improves the biocompatibility, biodegradability, and low toxicity in human body [82,83]
Alginate Improves the stability and biocompatibility [84,85]
Polymethylmethacrylate (PMMA) Generally used as thermosensitive drug delivery and cell separation [86-88]
Polyacrylic acid (PAA) Improves stability and biocompatibility as well as bioconjugation [89,90]

Wu et al.

Wu et al. Nanoscale Research Letters 2008 3:397-415   doi:10.1007/s11671-008-9174-9

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