Figure 2.

Scheme for the magnetic NPs functionalization procedure described in this work. Steps 1A and 1B: ligand-exchange reactions. Step 2: acylation of hydroxyl groups to prepare ATRP surface initiators. Step 3A: surface-initiated ring opening polymerization of L-lactide. Steps 3B: surface-initiated ATRP. Step 4: deprotection or additional reaction after polymerization. Step 5: graftiong of endfunctionalized PEG chains onto the nanoparticle surface using amidation chemistry. From [57]