Open Access Nano Express

Nanoporous Silicified Phospholipids and Application to Controlled Glycolic Acid Release

SangHwa Kang, HyeSun Lee, Jiho Lee, Seongmin Jeong, Jinsub Choi, SangCheon Lee, KyungJa Kim and JeongHo Chang*

Author Affiliations

Korea Institute of Ceramic Engineering and Technology, Seoul, 153-801, South Korea

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Nanoscale Research Letters 2008, 3:355-360  doi:10.1007/s11671-008-9165-x

Published: 9 September 2008

Abstract

This work demonstrates the synthesis and characterization of novel nanoporous silicified phospholipid bilayers assembled inorganic powders. The materials are obtained by silicification process with silica precursor at the hydrophilic region of phospholipid bilayers. This process involves the co-assembly of a chemically active phospholipids bilayer within the ordered porosity of a silica matrix and holds promise as a novel application for controlled drug release or drug containers with a high level of specificity and throughput. The controlled release application of the synthesized materials was achieved to glycolic acid, and obtained a zero-order release pattern due to the nanoporosity.

Keywords:
Nanoporous; Phospholipids; Silicification; Sol–gel; Controlled release; Glycolic acid